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KMID : 0361720070180040370
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Korean Journal of perinatology
2007 Volume.18 No. 4 p.370 ~ p.377
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Differential gene expression in placenta of term pregnant women with and without Labor using cDNA microarray
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Kim A-Ri
Kim Ok-Kyoung
Seo Mi-Won
Yang Dong-Eun
Ahn Hyun-Young
Park In-Yang
Lee Gui-Se-Ra
Shin Jong-Chul
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Abstract
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Objective: cDNA microarray technology was used to comprehensively analyze gene expression in placenta of term women with labor compared to without labor.
Methods: Placental tissue was obtained from patients in spontaneous labor (n=5) and those not in labor (n=5) during Cesarean section of full term pregnancy. mRNA levels were examined through cDNA microarray using Agilent GeneSpringGX 7.3 (Agilent technology, USA). SPSS 11.0 was used for statistical analysis.
Results: Among total 38467 genes, 2374 genes were detected to be up-regulated in labor samples, while 12 genes were down-regulated. 40 genes of them were identified significantly up-regulated in levels of expression (up-regulated ≥ 5.0 fold, p<0.05). According to gene ontology analysis, they are associated with variable cell biologic functions including apoptosis, signal transduction, metabolic process, immune response, and transcription, etc.
Conclusion: This study suggests that our results could provide interesting clues to understand the initiation and the process of normal labor and might lead to further studies in a more targeted fashion.
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KEYWORD
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Labor, Placenta, Gene expression profiling
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